Fury’s two wins over Wilder have defined his second coming, following two and a half years out of the ring to deal with his mental health, drugs and alcohol struggles.
For purists though, his greatest achievement was the win that immediately preceded him stepping away from boxing – a November 2015 success over Wladimir Klitschko in Dusseldorf.
“People forget about the Klitschko fight,” Frampton says. “For me that is one of – if not the – greatest wins for a British fighter ever.”
Fury’s showmanship stepped up in the build-up. Dressed as Batman in a news conference, he told Klitschko that he had “as much charisma as my underpants”.
World champion Klitschko was a clear favourite, unbeaten in 11 years and fighting with home advantage in his adopted Germany.
But Fury’s unrelenting mind games continued right up to fight night.
Just hours before the opening bell, Fury complained about the softness of the ring canvas, arguing it would hinder his footwork and that Klitschko had begun wrapping his hands without a member of Fury’s team present.
A layer of foam was removed from the surface, Klitschko rewrapped his hands, and, having had his demands met, Fury shone in the ring.
“He boxed Klitschko’s head off. He took him to school,” says Fury’s promoter Frank Warren.
The victory handed Fury the IBF, WBA and WBO world titles – three of the belts that Usyk is putting on the line in Riyadh this weekend.
“Tyson changed the landscape of the heavyweight division,” Warren adds. “And if he hadn’t vacated the belts because of his personal problems after the Klitschko fight, he would still have all those belts today.”
Aesthetically, Fury does not resemble a typical elite-level athlete.
“You couldn’t beat a fat man,” he mocked Klitschko before a scheduled rematch that never happened.
Taking his top off and proudly parading his paunch is a regular occurrence in Fury’s news conferences.
In many ways the lack of bulging muscles or six-pack has endeared him to the British public.
He has been lauded as the peoples’ champion, taking phone calls from fans when his mobile number was leaked online by his wife or buying shots for England football fans at Euro 2016.
But not everyone wants to be represented by him. Controversy and, occasionally, apologies have been a constant throughout Fury’s career.
Fury has made disparaging comments towards women, the Jewish community and homosexuals during his career.
After beating Klitschko he tested positive for a banned steroid, blaming it on consuming uncastrated wild boar.
He has links to suspected Irish gangster Daniel Kinahan, who had been a personal adviser to the boxer.
But Fury has been nimble outside the ring as well as inside it, slipping on to the next thing.
A Christmas single with Robbie Williams and numerous appearances on prime-time talk shows have kept him front and centre as one of boxing’s biggest stars.
“I think people identify with him because of the ups and downs of his life,” Warren says.
“He’s gone through a lot of what other people go through. Everybody knows somebody who’s had problems in their life. Everybody knows someone who’s had a drug problem, or a booze problem.
“They have seen how he’s dealt with it, come back from it.”
With his global fame, Fury has become less open with the media – but he has found other avenues for his trash talk.
Fury has directed expletive-laden social media posts at Usyk before their meeting, repeatedly describing his fellow champion as a “foreigner”.
Price, who has seen Fury slowly back up all his teenage bravado, sees a common thread.
“Deep down he is probably the same Tyson he has always been,” Price says.
“If he’s got it in for someone, the old, nasty mouth will come out.
“He gets personal. If he’s threatened by someone, he will get a bit nasty.”
Fury may not be able to break the iron-willed Usyk – a man who defended his native Ukraine against the Russian invasion five months after becoming champion.
If he does, securing a career-defining win and a full house of heavyweight belts, some have suggested the 35-year-old may retire.
But the man himself has suggested otherwise, promising at least a rematch against Usyk, plus two fights against Anthony Joshua before another meeting with Ngannou before he hangs up his gloves.
Predicting Fury’s next move is as tricky as ever. However long he has left in the sport, though, the blend of good, bad and ugly is sure to continue.